Transforming the Treatment Landscape in Oncology
At Incyte, we are harnessing breakthrough science to deliver medicines that may offer patients new treatment options. For decades, we have leveraged expertise in medicinal chemistry and biology to explore different approaches that evolve how therapies are developed and delivered to patients on their treatment journey.
Patients and their loved ones have support every step of the way.
Despite progress, cancer continues to be a leading cause of death worldwide, impacting millions of people. Given the significant unmet medical need and breadth of cancers, many of which have limited treatment options, we are purposeful in advancing research in areas where we believe we can have the greatest impact.
We take a comprehensive approach to identifying new treatments for patients with cancer, enabling us to explore both single agents and combinations of targeted and immunotherapies from both within and beyond our portfolio. We also collaborate with major universities and other companies to bring additional discovery platforms and therapeutics forward.
Our targeted therapy discovery efforts focus on identifying therapeutic intervention points within interdependent pathways that drive tumor growth, enabling us to leverage cross-program knowledge. Complementary to that is our immunotherapy discovery strategy, which is built on a deep understanding of functional genomics, pharmacodynamics and state-of-the-art bioinformatics. Insights into the nuances of immune surveillance in health and disease are leading us to new opportunities to harness the immune system to fight cancer. Our world-class chemistry and biology groups apply these learnings to develop small molecule, monoclonal antibody and bispecific antibody drug candidates for clinical testing.
Our Science-Driven Approach in Action
We strive to identify patients who may benefit from targeting specific immune regulatory pathways to activate innate and adaptive immunity. Learnings from our trials allow continual refinement of our approaches with the goal of customizing immunotherapy for cancer patients.
- For example, targeting multiple T-cell immune checkpoints, such as LAG-3, TIM-3 and PD-1, may be a way to improve on the progress achieved by targeting PD-1 alone.
Additionally, we are pursuing novel points of synergy and complementary mechanisms of action that have the potential to improve efficacy or the safety profile of our therapies. For example:
- Incyte is a leader in the discovery and development of therapies for patients with myeloproliferative neoplasms (MPNs) and graft-versus-host disease (GVHD). We have multiple clinical trials evaluating monotherapy and combination strategies to improve and expand treatments for patients with MPNs and GVHD. These include ruxolitinib-based combinations with BET and ALK2, new therapeutic options including axatilimab and novel targets such as mutant CALR.
Approved Therapies
![Incyte logo with text – Global Medical Information](https://cdn.incyte.com/2023-02/oncology_incyte_medical_information_logo%402x.png)
Incyte is committed to providing timely and accurate product information to healthcare professionals upon request. If you are seeking medical information on our products, or wish to meet with a Medical Science Liaison, please visit IncyteMI.com.
To report a possible Adverse Event or Product Complaint related to an Incyte product, contact Incyte Medical Information by calling 1-855-4-MEDINFO (1-855-463-3463).
![Incyte logo with text – Global Medical Information](https://cdn.incyte.com/2023-02/Incyte_GlobalMedInfo_logo_RGB_1color.png)
Incyte is committed to providing timely and accurate product information to healthcare professionals upon request. If you need medical information or have a medical question, please visit incyteglobalmedicalinformation.com.
To report a possible Adverse Event or Product Complaint related to an Incyte product, contact Incyte Global Medical Information.
Resources
FOR PATIENTS
![Image of Voices of MPN(registered trademark) Logo Image of Voices of MPN(registered trademark) Logo](https://cdn.incyte.com/2023-02/resources_voices_of_mpn_logo_t%402x.png)
Voices of MPN is an online platform that links people in the U.S. affected by myeloproliferative neoplasms (MPNs) to disease information, educational programs, helpful resources and tips and community activities. This initiative also invites patients and caregivers to share their stories and spread awareness about these rare, chronic blood cancers.
![Image of TestMyCholangio - Know the Next Step Image of TestMyCholangio - Know the Next Step](https://cdn.incyte.com/2023-08/resources_test_my_cholangio_logo_t%402x.png)
TestMyCholangio is a website designed to educate patients in the U.S. with cholangiocarcinoma about molecular profiling and the role it may play in informing management decisions. Here, patients can find information and resources to help encourage productive discussions with their healthcare professionals.
![Image of GVHD now Logo with text – Your health can't wait Image of GVHD now Logo with text – Your health can't wait](https://cdn.incyte.com/2023-02/resources_gvhd_now_logo_t%402x.png)
This site can help patients and caregivers understand graft-versus-host disease (GVHD) with information and an array of resources to provide support along the road toward health after transplant.
![Image of IncyteCares logo a program that offers access, reimbursement, education and support. Image of IncyteCares logo a program that offers access, reimbursement, education and support.](https://cdn.incyte.com/2023-02/resources_incytecares_logo_t%402x.png)
Through IncyteCARES—a patient support and assistance program for eligible patients prescribed Jakafi, Pemazyre, or Opzelura—we strive to implement initiatives that support patients and remove barriers to accessing these medicines in the U.S. Our team can help patients with understanding their insurance coverage, exploring financial assistance options and providing as-needed support.
FOR HEALTHCARE PROFESSIONALS
![Image of MPN CONNECT Logo](https://cdn.incyte.com/2023-02/oncology_mpn_connect_logo%402x.png)
From articles and diagnostic tools to videos and podcasts from industry leaders, MPN Connect offers a variety of professional resources about myeloproliferative neoplasms (MPNs)—including myelofibrosis, polycythemia vera and essential thrombocythemia.
![FGFR SCIENCE Logo](https://cdn.incyte.com/2023-02/oncology_fgfrscience_logo.png)
FGFRScience is a website that helps inform healthcare professionals about the role of FGFR2 fusions in intrahepatic cholangiocarcinoma. Discover how proactively identifying these clinically significant genomic alterations through next generation sequencing may help inform how each patient's disease is managed.
![Incyte logo with text – Global Medical Information](https://cdn.incyte.com/2023-02/oncology_incyte_medical_information_logo%402x.png)
Incyte is committed to providing timely and accurate product information to healthcare professionals upon request. If you are seeking medical information on our products, or wish to meet with a Medical Science Liaison, please visit IncyteMI.com.
To report a possible Adverse Event or Product Complaint related to an Incyte product, contact Incyte Medical Information by calling 1-855-4-MEDINFO (1-855-463-3463).
FOR HEALTHCARE PROFESSIONALS
![CHOLANGIOCARCINOMA EXISTS Logo](https://cdn.incyte.com/2023-02/oncology_eurpean_cholangiocarcinoma_network_logo%402x.png)
The Cholangiocarcinoma Europe website helps European healthcare professionals learn more about cholangiocarcinoma (CCA). CCAs are diverse biliary epithelial tumors involving the intrahepatic, perihilar and distal parts of the biliary tree. Each anatomical subtype has distinct epidemiology, molecular characteristics, prognosis and strategy for clinical management.
![Incyte logo with text – Global Medical Information](https://cdn.incyte.com/2023-02/Incyte_GlobalMedInfo_logo_RGB_1color.png)
Incyte is committed to providing timely and accurate product information to healthcare professionals upon request. If you need medical information or have a medical question, please visit incyteglobalmedicalinformation.com.
To report a possible Adverse Event or Product Complaint related to an Incyte product, contact Incyte Global Medical Information.