Explore Our Science

We have a breadth of clinical programs within our portfolio across Myeloproliferative Neoplasms (MPNs) and Graft-Versus-Host Disease (GVHD), General Hematology/Oncology, Dermatology and other Inflammation & Autoimmunity (IAI), and Partnered Programs.

Our Portfolio

Molecular Targets

17

Clinical Compounds

21

Approved Products

9
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MPNs and GVHD
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Jakafi® (ruxolitinib)1

JAK1/JAK2

Myelofibrosis2, polycythemia vera2, GVHD2

status for mobile

NiktimvoTM (axatilimab-csfr)3

CSF-1R

3L+ chronic GVHD2

status for mobile

ruxolitinib XR (QD)

JAK1/JAK2

Bioequivalence and stability testing

status for mobile

axatilimab3

CSF-1R

1L chronic GVHD | + ruxolitinib

status for mobile

zilurgisertib

ALK2

Myelofibrosis-associated anemia
| ± ruxolitinib

status for mobile

INCB057643

BET

Myelofibrosis | ± ruxolitinib

status for mobile

INCA033989

mutCALR

Myelofibrosis or ET with CALR mutation | ± ruxolitinib

status for mobile

INCB160058

JAK2-V617F

JAK2V617F-mutated myelofibrosis

status for mobile

General Hematology/Oncology
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Pemazyre® (pemigatinib)

FGFR1/2/3

2L+ cholangiocarcinoma4, MLNs with FGFR1 rearrangement2,5

status for mobile

Monjuvi® (tafasitamab-cxix)   
Minjuvi® (tafasitamab)

CD19

r/r DLBCL2,6,7

status for mobile

Iclusig® (ponatinib)8

BCR-ABL

Chronic myeloid leukemia6
Ph+ ALL6

status for mobile

Zynyz® (retifanlimab-dlwr)9
Zynyz® (retifanlimab)9

PD-1

Merkel cell carcinoma2,6

status for mobile

tafasitamab

CD19

r/r follicular lymphoma, r/r MZL,
1L DLBCL

status for mobile

retifanlimab9

PD-1

Squamous cell anal carcinoma, NSCLC

status for mobile

retifanlimab9

PD-1

MSI-H endometrial cancer

status for mobile

itacitinib

JAK1

Cytokine release syndrome

status for mobile

INCB123667

CDK2

Solid tumors

status for mobile

INCA3389010

TGFßR2×PD-1

Solid tumors

status for mobile

INCB161734

KRAS-G12D

KRASG12D-mutated solid tumors

status for mobile

Dermatology and Other IAI
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Opzelura® (ruxolitinib) cream

JAK1/JAK2

AD2, vitiligo2,6

status for mobile

ruxolitinib cream

JAK1/JAK2

Pediatric AD, prurigo nodularis, pediatric vitiligo

status for mobile

ruxolitinib cream

JAK1/JAK2

Hidradenitis suppurativa, lichen planus, lichen sclerosus

status for mobile

povorcitinib

JAK1

Hidradenitis suppurativa, vitiligo, prurigo nodularis

status for mobile

povorcitinib

JAK1

CSU, asthma

status for mobile

INCB000262 (EP262)

MRGPRX2

CSU, chronic inducible urticaria, AD

status for mobile

INCB000547 (EP547)

MRGPRX4

Cholestatic pruritus

status for mobile

zilurgisertib

ALK2

Fibrodysplasia ossificans progressiva

status for mobile

Partnered Programs
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Olumiant® (baricitinib)11

JAK1/JAK2

Rheumatoid arthritis12, COVID-1912, AD5,6, alopecia areata2,5,6

status for mobile

Tabrecta® (capmatinib)13

MET

NSCLC with METex1412

status for mobile

axatilimab3

CSF-1R

Idiopathic pulmonary fibrosis14

status for mobile

Updated as of August 27, 2024

Please refer to local prescribing information for more information, including full safety information, on Incyte’s marketed medicines, or on medicines marketed by Incyte’s collaboration partners. 

1. Marketed by Incyte in the U.S.; ruxolitinib licensed to Novartis outside the U.S. 2. Approved in the U.S. 3. In collaboration with Syndax
4. Approved in multiple territories, including the U.S., Canada, Europe, and Japan 5. Approved in Japan 6. Approved in Europe 7. Approved in Canada 8. European rights to Iclusig licensed from Takeda 9. Licensed from MacroGenics 10. Development in collaboration with Merus 
11. Worldwide rights to baricitinib licensed to Lilly 12. Approved in multiple territories globally 13. Worldwide rights to capmatinib licensed to Novartis 14. IPF study currently led and funded by Syndax

1L, first-line; 2L+, second-line or later; 3L+, third-line or later; AD, atopic dermatitis; ALL, acute lymphoblastic leukemia; CSU, chronic spontaneous urticaria; DLBCL, diffuse large B-cell lymphoma; ET, essential thrombocythemia; FGFR, fibroblast growth factor receptor; GVHD, graft-versus-host disease; IAI, inflammation and autoimmunity; IPF, idiopathic pulmonary fibrosis; mAb, monoclonal antibody; MLNs, myeloid/lymphoid neoplasms; MPNs, myeloproliferative neoplasms; MSI-H, microsatellite instability-high; mut, mutant; MZL, marginal zone lymphoma; NSCLC, non-small cell lung cancer; Ph+, Philadelphia chromosome-positive; QD, once daily; r/r, relapsed or refractory; XR, extended release.

Clinical Trials

At Incyte, we believe in the power of research to advance scientific innovation and improve patient health. Thanks to the ongoing dedication of the people who participate in our clinical trials, we strive to develop medicines that have the potential to make a meaningful difference in the treatment of disease.

Our Incyte Clinical Trials website provides information for patients and healthcare professionals, including the basics of how clinical trials work and details about clinical studies that Incyte is currently sponsoring across a number of therapeutic areas, including Oncology and Inflammation & Autoimmunity.

Clinical Trial Information for U.S. Patients

Clinical Trial Information for Healthcare Professionals

Are you a physician, researcher or institution representative interested in conducting external research?

Incyte supports significant independent research aimed at enhancing disease understanding and advancing the study of our products by generating health outcomes data and real-world evidence.

Proposals submitted to Incyte are reviewed by Incyte's scientific and medical committees, with approval based on scientific merit, patient-safety considerations, unmet medical needs, study design, availability of resources and feasibility of study conduct. If you’re interested in submitting a research proposal, please visit our online research portal.

For questions concerning Investigator Initiated Research conducted outside of the U.S., please contact Incyte at global_iir@incyte.com.

For questions concerning Investigator Initiated Research conducted in the U.S., please contact Incyte at us_iir@incyte.com.

 

Visit our company response page on COVID-19.

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